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In this study, we screened the PRESTWICK CHEMICAL LIBRARY composed of 1,520 approved drugs in an infected cell-based assay. The robustness of the screen was assessed by the identification of drugs that already demonstrated in vitro antiviral effect against SARS-CoV-2. Thereby, 90 compounds were identified as positive hits from the screen and were grouped according to their chemical composition and their known therapeutic effect. Then EC50 and CC50 were determined for a subset of 15 compounds from a panel of 23 selected drugs covering the different groups. Eleven compounds such as macrolides antibiotics, proton pump inhibitors, antiarrhythmic agents or CNS drugs emerged showing antiviral potency with 2 < EC50 ≤ 20 µM. By providing new information on molecules inhibiting SARS-CoV-2 replication in vitro, this study provides information for the selection of drugs to be further validated in vivo.

Among these 90 hits, we identified drugs that previously demonstrated to inhibit in vitro the SARS-CoV2 replication. Accordingly, Chloroquine and Hydroxychloroquine13,14,15,16 were shown to limit in vitro SARS-CoV-2 replication with an Inh. Index of 1.35 and 1.43 respectively. In addition to chloroquine derivatives, two other hits are also currently evaluated in different clinical trials, namely Darunavir17 and Azythromycine18.

Gadianton wrote: ↑

Sun Oct 17, 2021 2:19 am

For those moved by Joe Rogan's defense of the deworming chemical Ivermectin, please consider alternatives and let's save the horses and pigs from the right-ring run on livestock medicines.

Joe repeated over and over that Ivermectin was effective against Covid "in vitro" and therefore, it should be taken seriously as a real treatment.

https://www.nature.com/articles/s41598-020-70143-6

Here are some alternatives.

In this study, we screened the PRESTWICK CHEMICAL LIBRARY composed of 1,520 approved drugs in an infected cell-based assay. The robustness of the screen was assessed by the identification of drugs that already demonstrated in vitro antiviral effect against SARS-CoV-2. Thereby, 90 compounds were identified as positive hits from the screen and were grouped according to their chemical composition and their known therapeutic effect. Then EC50 and CC50 were determined for a subset of 15 compounds from a panel of 23 selected drugs covering the different groups. Eleven compounds such as macrolides antibiotics, proton pump inhibitors, antiarrhythmic agents or CNS drugs emerged showing antiviral potency with 2 < EC50 ≤ 20 µM. By providing new information on molecules inhibiting SARS-CoV-2 replication in vitro, this study provides information for the selection of drugs to be further validated in vivo.

Among these 90 hits, we identified drugs that previously demonstrated to inhibit in vitro the SARS-CoV2 replication. Accordingly, Chloroquine and Hydroxychloroquine13,14,15,16 were shown to limit in vitro SARS-CoV-2 replication with an Inh. Index of 1.35 and 1.43 respectively. In addition to chloroquine derivatives, two other hits are also currently evaluated in different clinical trials, namely Darunavir17 and Azythromycine18.

Here are some more "in vitro" success stories:

Remdesivir
Azithromycine
Spirámycin
Omeprazole
Alprostadil
Oxprenolol hydrochloride
Hydroxy-chloroquine
Clemizole hydrochloride
Spiperone
Arbidol
Dyclonine hydrochloride
Azit
Azithromycine
Spirámycin
Omeprazole
Alprostadil
Oxprenolol hydrochloride
Dolutegravir
Sulfadoxine
Quinidine 10 hydrochloride
Vonoprazan
Exemestane
Opipramol dihydrochloride
Dyclonine hydrochloride
Dolutegravir

If success "in vitro" is good enough to write a prescription, then lets spread the joy around and spare the farm animals of the world a whole lot of extra pain by raiding one of their most important medicines.

Cult wrote:The populist movements are not about Trump, they are about the cabals, Schmo and Gadianton...

Ceeboo wrote:truth

We talked about girlfriends, guns, kids, grandkids, daughters in law, sons in law, the Giants, Dodgers and Red Sox. We talked about the fire department, sheet metal prices, custom guns, reloading, boat tail bullets.

Until ivermectin’s use as both a preventive and treatment agent are more widely accepted or recommended, many physicians will be reluctant to prescribe.

If your doctor will not prescribe ivermectin for you, please contact one of the providers listed below.